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The Next Paradigm Shift
Programmable
NNP Delivery
Platform
You discover. We deliver breakthroughs.
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Why a Paradigm Shift?

Drug discovery has
leapt ahead.
Delivery still lags.

Conventional delivery systems face fundamental limitations in toxicity, redosing, and extrahepatic targeting.
GEN 0
Naked Drug
No targeting
GEN 1
LNP / AAV
Toxicity limits
NEXT GEN
SHIFTBIO NNP
✓ Targeted
✓ Versatile
✓ Redosable
✓ Scalable
You discover. We deliver breakthroughs.
Transforming your therapeutic assets
into groundbreaking therapies, together.

The Next Paradigm Shift

Every essential. One particle.

Natural Nanoparticles (NNPs)Cell-derived. Programmable. Plug-and-play targeting and loading for your cargo.

  1. 01Targeted delivery
  2. 02Barrier crossing
  3. 03Versatile payload
  4. 04Repeat dosing
  5. 05Scalable manufacturing
Explore technology Partner with us

Animated schematic: particles gather into the SHIFTBIO mark, a cell split by a turning curve; a small particle is born at its centre and comes forward as a programmable NNP. Its five surface docks light up, and each is linked to its label: targeted delivery, barrier crossing, versatile payload, repeat dosing and scalable manufacturing.

New medicines needa new way in.

Schematic: the view moves along the inside of a blood vessel lined with cells, and particles gather into a single NNP at the closing period.

Five essentials of next-generation delivery

  1. 01

    Targeted delivery

    Reach target tissues beyond the liver.I-NNP

  2. 02

    Barrier crossing

    Cross the blood–brain barrier, cell membranes and endolysosomes.B-NNP

  3. 03

    Versatile payload

    Load more cargo, and more kinds of drugs.NNP technology

  4. 04

    Repeat dosing

    Allow repeated doses with high purity and dramatically lower cost.NNP technology

  5. 05

    Scalable manufacturing

    Scale up with batch-to-batch consistency.NNP technology

Program. Predict. Produce.

NNP technology · Step 01

Program.

Plug-and-play targeting and loading.

NSM scaffoldExplore NSM scaffold

Schematic: one NNP assembles around its cargo; a set of targeting motifs clicks onto its surface and is swapped for another set on the same scaffold.

NNP technology · Step 02

Predict.

From uncertainty to predictability.

NNP Design AIExplore NNP Design AI

Schematic: candidate cargo and linker designs pour out of the NNP into a wall, are ordered by predicted cargo sorting from bright to dim; the first few light up to build first, and assay results return to the loop.

NNP technology · Step 03

Produce.

Reproducible at scale.

NNP manufacturingExplore manufacturing

Schematic: uneven cell-derived nanoparticles pass an industrialization gate one by one and come out as consistent NNPs stacked in a grid.

Delivery platforms

01 · Targeted delivery

Built forthe destination.

One NNP technology. Two delivery platforms.

I-NNP

Immune-mediated diseases

CD47-guided delivery, with CD47 blockade built in.

CD47 BINDING & ACCUMULATION
Healthy tissueInflamed tissueCD47 highCD47
Targeting · CD47 blockade · Cargo deliverySurface SIRPα engages CD47
Explore I-NNP

B-NNP

CNS disorders

One surface motif docks at the blood–brain barrier, the other crosses it.

DOCK AND TRANSCYTOSE
BloodBlood–brain barrier01Dock02Cross03DeliverBrain tissue
Anchoring motifTranscytosis motif
Explore B-NNP

Publications

Publishedscience.

All publications

  1. Nature CommunicationsPublished 2025IF 18.1JCR 2026

    Engineering, manufacturing and therapeutic function.

    Dual-mode action of scalable, high-quality engineered stem cell‑derived SIRPα-extracellular vesicles for treating acute liver failure.

  2. Kidney InternationalPublished 2026IF 21.8JCR 2026

    Delivery that engages the immune system.

    Therapeutic reprogramming of circulating myeloid cells via signal regulatory protein α extracellular vesicles in acute kidney injury.

People

The peoplebehind the platform.

Bridging biology, AI, and engineering to deliver where it matters most.

Meet the team

News

Latest fromSHIFTBIO.

All news

Partnering

You discover.We deliverbreakthroughs.

Partners bring the payload and the target biology. We bring NNP technology and delivery platforms.

  • Platform licensing
  • Evaluation agreements
  • Co-development
Discuss your payload